(1S,4R)- 4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Dihydrogen Phosphate (Ester); (1S-cis)-Abacavir Monophosphate; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Metabolites
雜質(zhì):
Abacavir - In House Impurity
CAS號(hào):
136470-77-4
分子式:
C??H??N?O?P
狀態(tài)：
白色固體
熔點(diǎn)：
189-194°C (dec.)
分子量:
366.31
儲(chǔ)存：
-20?C Freezer
溶解性:
Methanol, Water
類別:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:
Abacavir 5’-Phosphate (Abacavir - In House Impurity) is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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