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產品基本信息

產品編號：S870000

產品名稱：Suvorexant

產品CAS：1030377-33-3

規格含量：50mg

產品價格：面議

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產品詳細介紹

標準品編號:	S870000
名稱:	Suvorexant
別名:	[(7R)-4-(5-Chloro-2-benzoxazolyl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]-methanone;5-Chloro-2-[(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl]-1,3-benzoxazole; MK 4305; [(R)-4-(5-Chloro-benzooxazol-2-yl)-7-methyl-[1,4]diazepan-1-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone
CAS號:	1030377-33-3
分子式:	C??H??ClN?O?
外觀:	白色至Pale Beige Solid
熔點:	131-133°C
分子量:	450.92
儲存:	Room Temperature
溶解度:	Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
類別:	Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
應用:	Suvorexant (MK-4305) is a dual (non-selective) orexin receptor antagonist in development by Merck & Co. for the treatment of insomnia. It works by turning off wakefulness rather than by inducing sleep. Users of higher doses had an increased rate of suicidal ideation.
參考文獻	Cox, C., et al.: J. Med. Chem., 53, 5320 (2010); Baxter, C., et al.: Org. Process Res. Dev., 15, 367 (2011); Winrow, C., et al.: J. Neurogenet., 25, 52 (2011); Mieda, M., et al.: CNS Drugs, 27, 83 (2013); Osborne, R.: Nat. Rev. Drug Discov., 12, 492 (2013)

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