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| 產品基本信息 |
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| 產品編號：125063 |
| 產品名稱：MMAD, ≥99% |
| 產品CAS：203849-91-6 |
| 規格含量：5MG |
| 產品價格：6300 |
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| 產品詳細介紹 |
MMAD, ≥99%
Product Name： MMAD
CAS號:203849-91-6
分子式:C41H66N6O6S
分子量:771.06
貯存： 儲存溫度-20°C
可溶性： 25°C： DMSO
生化和生理學機理：
Description：
Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate.
For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABVIP(LA)MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent： WO 2013068874 A1).
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