RG2833, ≥98%
Product Name： RG2833
CAS號:1215493-56-3
分子式:C20H25N3O2
分子量:339.43
貯存： 儲存溫度-20°C
可溶性： 25°C： DMSO
生化和生理學(xué)機理：
Description：
IC50 Value： N/A
RGFP 109 is a histone deacetylase inhibitor which can attenuate L-DOPVIP(LA)induced dyskinesia in the MPTP-lesioned marmoset.
in vitro： N/A
in vivo： RGFP109 had no acute effects on dyskinesia after single or 6 days once-daily treatment (both P > 0.05). However, one week following cessation of RGFP109, dyskinesia and duration of ON-time with disabling dyskinesia were reduced by 37% and 50%, respectively (both P < 0.05), compared to that seen previously with L-DOPA alone. There was no change in anti-parkinsonian actions of, or ON-time duration afforded by, L-DOPA (P > 0.05) [1].
Clinical trial： Phase 1
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